This weekend is the first ever DC Comic Con in the Washington, DC, suburbs. It takes place on Sunday, May 2nd, and has some good guests lined up. This one is a small, one day event, no doubt testing the waters to see if they should expand next year.
Tampa, FL. has the Vulcan Events media con, which interestingly enough does not seem to have a single primary Star Trek actor, but it does have a ton of stars of other programs (and a few have been in Trek episodes or movies). In Charlotte, NC, is this weekends Twighlight Con for those looking for a different flavor of media con.
Nashville Anime fans will be holding forth at the Middle Tennessee Anime Convention, which is a much more complex and well rounded event than a first glance would indicate. With a large assortment of tracks, and every one of them full of events and entertainments of all sorts, this is one I need to try to attend next year. I would pay the full price just for the music track concerts, panels, and other events, and wedge in as much other fun as I could squeak in. It looks like staying awake for the full 72 hours would be the only acceptable option for this one.