COSine 2010 is a ReaderCon with GoH L.E.Modesitt Jr., happening from the 22nd to the 24th in Colorado Springs. Another fan-run gathering is ConFusion 2010; it runs from the 22nd to the 25th, and is the annual Science Fiction convention hosted by the Stilyagi Air Force of Ann Arbor.
The main MediaCon this weekend is the Salute to Star Trek in San Francisco from the 22nd to the 24th. Primary GoH’s are William Shatner and Patrick Stewart, but there will be a ton of others there as well.
Further ConFusion takes place in San Jose, CA, from the 21st to the 25th. Now in its 12th year, FurCon is one of the largest anthropomorphic (aka “furry”) conventions in North America.
On the 23rd through the 26th (they are running from Saturday through Tuesday because Tuesday is a national holiday), ArcanaCon XXVIII takes place in Melbourne, Australia. This is primarily a GamerCon, with the emphasis at the RPG end of the spectrum.
For Anime conventions, the SoDak Anime Convention happens from the 23rd to the 25th in Rapid City, South Dakota. Guests include Voice Actors Vic Mignogna and Wendy Powell, and something no anime con should be without: their own in-house roller derby team, the Rushmore Rollerz, who run under a theme song by Florence and the Machine, A Kiss With The Fist.